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September 10, 2025JACS AuOpen Access

Lysine-Targeting Inhibitors of Amyloidogenic Protein Aggregation: A Promise for Neurodegenerative Proteinopathies

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Authors

KMKazuma MurakamiTNThi Hong Van NguyenCNChioko Nagao

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Overview

Inhibition of protein aggregation in various proteinopathies using lysine-targeting compounds shows potential, suggesting therapeutic advancements.

Key Points

  • Compounds targeting lysine residues effectively disrupt protein aggregation associated with neurodegenerative diseases.
  • Recent findings demonstrate promising results from lysine-targeting inhibitors in animal models of proteinopathies like Alzheimer's.
  • This approach leverages both covalent and noncovalent interactions to impede amyloidogenic protein self-assembly mechanisms.
  • The application of lysine inhibitors could pave the way for novel therapeutic strategies to combat multiple forms of proteinopathies.

Cite This Study

Murakami et al. (2025) studied this question.

synapsesocial.com/papers/68c1c23554b1d3bfb60efc53https://doi.org/10.1021/jacsau.5c00269
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Beyond Amyloid: Targeting Co-Aggregating Proteins and Targeted Degradation Strategies in Alzheimer’s Disease2026 · 2 citations
  2. 2Recent Advances in Mapping Protein Self-Assembly and Aggregation for Common Proteinopathies2024 · 1 citations
  3. 3Polymeric Materials as a Promising Platform for Suppressing Protein Aggregation Process2024 · 3 citations
  4. 4Chemical Strategies to Modulate Amyloidogenesis Associated with Neurodegenerative Diseases2026
  5. 5Molecular and Technological Advances in the Treatment of Protein Misfolding Disorders2025