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September 10, 2025Infection and Drug ResistanceOpen Access

Emergence, Molecular Characteristics and Resistance Mechanisms of Colistin-Resistant Enterobacterales in Xuzhou, China

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Authors

SZShulong ZhaoNational University of Defense TechnologyXLXinyi LiangChildren's Hospital of Zhejiang UniversityHLHuihui LiXinjiang Medical University

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Overview

Analysis reveals colistin resistance mechanisms in Klebsiella pneumoniae and Escherichia coli, suggesting emerging public health threats.

Key Points

  • Inactivation of the mgrB gene leads to colistin resistance in carbapenem-resistant Klebsiella pneumoniae strains.
  • Four plasmids carrying resistance genes were identified in colistin-resistant Escherichia coli strains, highlighting genetic diversity.
  • Pulsed-field gel electrophoresis indicated potential epidemics of colistin-resistant strains within the community.
  • The study enhances support for local epidemiological knowledge, critical for managing the spread of colistin resistance.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68c1c23d54b1d3bfb60efd2dhttps://doi.org/10.2147/idr.s526613
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