June 2, 2024CureusOpen Access

Investigation of Plasmid-Mediated Colistin Resistance Genes (mcr-1–8) in Enterobacterales Isolates

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Authors

MGMelahat GürbüzDepartment of Medical Sciences EŞEmek Türkekul ŞenMinistry of Health MŞMerih ŞimşekMinistry of Health

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Implication

Prospective study demonstrates absent mcr-1 to mcr-8 genes in colistin-resistant Enterobacterales, suggesting alternative resistance mechanisms predominate.

Key Points

Colistin resistance occurred in 34.2% of carbapenem-resistant Enterobacterales isolates, but none harbored plasmid-mediated mcr-1 to mcr-8 genes.
Broth microdilution confirmed colistin resistance across 27 isolates, while multiplex PCR testing verified the complete absence of mcr targets.
Findings highlight that colistin resistance in these clinical Enterobacterales isolates likely stems from alternative chromosomal mechanisms.

Cite This Study

Gürbüz et al. (2024) studied this question.

synapsesocial.com/papers/68e66995b6db6435875f4e2c https://doi.org/10.7759/cureus.61538

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Implication

Prospective study demonstrates absent mcr-1 to mcr-8 genes in colistin-resistant Enterobacterales, suggesting alternative resistance mechanisms predominate.

Investigation of Plasmid-Mediated Colistin Resistance Genes (mcr-1–8) in Enterobacterales Isolates

Discussion

Member takes

Implication

Key Points

Cite This Study

Investigation of Plasmid-Mediated Colistin Resistance Genes (mcr-1–8) in Enterobacterales Isolates

Discussion

Member takes

Implication

Key Points

Cite This Study

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