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September 10, 2025CellsOpen Access

Multi-Omic Characterization of Epithelial–Mesenchymal Transition: Lipidomic and Metabolomic Profiles as Key Markers of TGF-β-Induced Transition in Huh7 Hepatocellular Carcinoma

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Authors

ABAgnese BertoldiUniversity of Perugia GCGaia Cusumano ECEleonora CalzoniUniversity of Perugia

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Implication

This analysis reveals lipidomic and metabolomic alterations during epithelial-mesenchymal transition in Huh7 cells, suggesting TGF-β's role in cancer progression.

Key Points

TGF-β1-induced EMT results in significant alterations in lipidomic and metabolomic profiles.
Lipidomic profiling showed increased ceramides and modified phospholipid classes during the transition.
Metabolomic analysis indicated altered choline metabolism, reflecting changes in mitochondrial function.
The findings highlight the role of metabolic reprogramming in sustaining the EMT process in cancer.

Cite This Study

Bertoldi et al. (2025) studied this question.

synapsesocial.com/papers/68c1c23d54b1d3bfb60efec2 https://doi.org/10.3390/cells14161233

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Implication

This analysis reveals lipidomic and metabolomic alterations during epithelial-mesenchymal transition in Huh7 cells, suggesting TGF-β's role in cancer progression.

Multi-Omic Characterization of Epithelial–Mesenchymal Transition: Lipidomic and Metabolomic Profiles as Key Markers of TGF-β-Induced Transition in Huh7 Hepatocellular Carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

Multi-Omic Characterization of Epithelial–Mesenchymal Transition: Lipidomic and Metabolomic Profiles as Key Markers of TGF-β-Induced Transition in Huh7 Hepatocellular Carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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