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September 10, 2025PharmaceuticsOpen Access

Recent Advances in Nanomedicine: Cutting-Edge Research on Nano-PROTAC Delivery Systems for Cancer Therapy

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Authors

XWXiaoqing WuQilu University of TechnologyYSYueli ShuSichuan UniversityZYZheng YaoNanjing Jiangning Hospital

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Overview

This review uncovers how nanodrug delivery enhances PROTAC effectiveness in cancer therapy, suggesting novel approaches for improved clinical outcomes.

Key Points

  • Nano-PROTAC delivery systems significantly enhance solubility and biostability, reducing off-target toxicity while improving therapeutic efficacy.
  • Recent advances in delivery techniques include physical encapsulation, chemical conjugation, and intelligent delivery systems, emphasizing their potential in cancer therapy.
  • The study reviews diverse nanomaterial carriers such as lipid-based and polymeric nanoparticles, evaluating their role in PROTAC delivery systems.
  • Insights presented could facilitate the clinical translation of innovative nanocarrier systems for PROTACs, addressing current challenges.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68c1c23d54b1d3bfb60effb0https://doi.org/10.3390/pharmaceutics17081037
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nano-Proteolysis Targeting Chimeras (Nano-PROTACs) in Cancer Therapy2024 · 43 citations
  2. 2Advancing PROTAC therapeutics through chemistry-guided design of smart delivery systems2026
  3. 3Photo‐Assisted NanoPROTACs for Targeted Cancer Therapy2026
  4. 4Nanoplatform‐Based Delivery Systems for PROTACs2026
  5. 5Contemporary Developments in PROTACs for Cancer Management: An In-Depth Review2026 · 1 citations