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June 27, 2026Acta Pharmacologica SinicaOpen Access

Advancing PROTAC therapeutics through chemistry-guided design of smart delivery systems

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Authors

TYTingting YaoZZZheng ZhouGWGuangji Wang

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Overview

Review presents chemistry-driven strategies to enhance the delivery and efficacy of PROTAC therapeutics, indicating potential for improved clinical application.

Key Points

  • To explore the chemistry-driven design of delivery systems for enhancing the therapeutic potential of PROTACs.
  • Review of medicinal chemistry and delivery strategies for PROTACs.
  • Discussion of innovations in prodrug and linker engineering for controlled release.
  • Analysis of various delivery vehicles including lipid-based and polymeric systems.
  • Proposed delivery strategies enhance cellular uptake and target selectivity.
  • Innovations achieve precise spatiotemporal regulation of PROTAC activity.
  • Emergence of programmable medicinal chemistry enhances pharmacokinetic optimization.

Cite This Study

Yao et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6817aea7db3c1953f454https://doi.org/10.1038/s41401-026-01853-2
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