Prospective study identifies drug-related problems in patients using high-risk medications, suggesting interventions to improve outcomes.
Background: Drug-Related Problems (DRPs) associated with High-Risk Medications (HRMs) present significant challenges in clinical practice, particularly among older adults with multiple comorbidities. This study aimed to identify, classify, and address DRPs in patients prescribed HRMs at a tertiary care hospital in Kerala. Methods: A prospective interventional study was conducted over ten months, enrolling 201 patients aged 18 years and above, of whom 193 completed the protocol. Prescriptions involving HRMs from the cardiology, neurology, general medicine, and psychiatry departments were reviewed using the APS-Doc framework to classify DRPs. Pharmacist-led interventions were implemented to resolve identified issues, including dosage adjustments, drug substitutions, and enhanced patient monitoring.
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A et al. (2025) studied this question.
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