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September 10, 2025

Cascade of Calamity: Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Complicated by Acute Kidney Injury, Heart Failure, and Sepsis – A Case Report of Suspected Ciprofloxacin/Co-trimoxazole Trigger

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Case report details severe multi-organ failure due to SJS/TEN triggered by ciprofloxacin and co-trimoxazole, highlighting complex management.

Severe multi-organ failure can complicate stevens-johnson syndrome/toxic epidermal necrolysis, indicating dire outcomes.
The patient presented with acute kidney injury and heart failure alongside SJS/TEN following drug exposure to ciprofloxacin.
Management in the ICU involved corticosteroids and intravenous immunoglobulin due to the patient's dramatic clinical decline.
This case stresses the need for monitoring multi-system organ failure in SJS/TEN, as it can escalate rapidly and require multidisciplinary care.

Ahmadi et al. (2025) studied this question.

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Case report details severe multi-organ failure due to SJS/TEN triggered by ciprofloxacin and co-trimoxazole, highlighting complex management.