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September 10, 2025

Plasma Interleukin-12 Levels as a Potential Biomarker of Fatigue and Quality of Life in Primary Immune Thrombocytopenia

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Authors

SWSarthak WadheraPost Graduate Institute of Medical Education and ResearchAJArihant JainCalifornia University of PennsylvaniaASAarushi SahniPost Graduate Institute of Medical Education and Research

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Overview

Observational study links elevated interleukin-12 levels to increased fatigue in immune thrombocytopenia patients, indicating potential biomarker status.

Key Points

  • ITP patients experience significantly lower quality of life and higher fatigue compared to healthy controls.
  • IL-12 levels in ITP patients averaged 313.2 pg/mL, correlating negatively with FACIT scores indicating poor health-related quality of life.
  • Patients showed notable correlations between fatigue, disease duration, elevated IL-12 levels, and female sex, impacting HRQoL.
  • The study highlights IL-12's potential as an immunologic biomarker for assessing fatigue in ITP.

Cite This Study

Wadhera et al. (2025) studied this question.

synapsesocial.com/papers/68c1c24454b1d3bfb60f005chttps://doi.org/10.21203/rs.3.rs-7030456/v1
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