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July 15, 2021British Journal of HaematologyOpen Access

Qualitative study to support the content validity of the immune thrombocytopenia (ITP) Life Quality Index (ILQI)

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Key result

Qualitative interviews confirmed the content validity of the ITP Life Quality Index in 15 adult patients, identifying key symptoms including bruising (100%) and fatigue (93.3%).

Why the study?

ITP negatively impacts health-related quality of life, and this study aimed to confirm the content validity of the 10-item ITP Life Quality Index (ILQI).

Does the ITP Life Quality Index (ILQI) accurately capture the symptoms and impacts associated with ITP in adult patients?

Population

15 adult participants with ITP in the UK

Design

Qualitative interview study

Authors

NCNichola CooperACAdam CukerNBNicola Bonner

Discussion

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Member takes

Overview

ILQI content validity supported in small adult ITP sample; leaves open quantitative validation before clinical adoption.

Structured PICO

Does the ITP Life Quality Index (ILQI) accurately capture the symptoms and impacts associated with ITP in adult patients?

P
Population
15 adult participants with immune thrombocytopenia in the UK participating in a qualitative interview study.
E
Exposure
Qualitative interview study (combined concept elicitation and cognitive debriefing interviews) using the ITP Life Quality Index (ILQI)
O
Outcome
Content validity of the ITP Life Quality Index (ILQI)patient reported

Qualitative interviews confirmed the content validity of the ILQI, ensuring it captures relevant symptoms and impacts for adult patients with ITP.

Cite This Study

Cooper et al. (2021) studied Immune thrombocytopenia (ITP) (n=15). ITP Life Quality Index (ILQI) was evaluated on Content validity of the draft ILQI. Qualitative interviews confirmed the content validity of the ITP Life Quality Index in 15 adult patients, identifying key symptoms including bruising (100%) and fatigue (93.3%).

synapsesocial.com/papers/6a9aef5f3ea1bd9df6be6523https://doi.org/10.1111/bjh.17694
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Changes in health‐related quality of life with long‐term eltrombopag treatment in adults with persistent/chronic immune thrombocytopenia: Findings from the EXTEND study2018 · 30 citations
  2. 2Grounded Theory and Sensitizing Concepts2006 · 1,886 citations
  3. 3Updated international consensus report on the investigation and management of primary immune thrombocytopenia2019 · 1,129 citations
  4. 4Immune thrombocytopenia (<scp>ITP</scp>) <scp>World Impact Survey</scp> (<scp>I‐WISh</scp>): Impact of <scp>ITP</scp> on health‐related quality of life2020 · 118 citations
  5. 5Impact of chronic Immune Thrombocytopenic Purpura (ITP) on health-related quality of life: a conceptual model starting with the patient perspective2008 · 111 citations