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September 10, 2025Frontiers in ImmunologyOpen Access

High-dimensional immune profiling of follicular fluid and systemic circulation reveals distinct immune signatures in women with polycystic ovary syndrome

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Elevated systemic inflammatory markers were noted in PCOS patients before treatment and partially normalized after oocyte retrieval.
The follicular fluid demonstrated higher levels of angiogenic factors like VEGF and EGF while plasma showed increased concentrations of various cytokines.
High-dimensional flow cytometry revealed distinct immune cell profiles in PCOS compared to controls, highlighting immune dysregulation.
Differential immune signatures across circulation and follicular fluid suggest therapeutic targets for managing PCOS.

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Prospective cohort study shows immune differences in follicular fluid and circulation in PCOS, indicating inflammation patterns.

Banerjee et al. (2025) studied this question.

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