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September 10, 2025Iranian Journal of Veterinary Medicine

Lycopene Ameliorates Chlorpyrifos-induced Neurotoxicity via Antioxidant and Anti-inflammatory Mechanisms in Rats

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Authors

PBParag Ranjita BeraSJSumanta JanaPMPrabir Mondal

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Overview

Observational analysis reports lycopene improves neuronal health in male rats exposed to chlorpyrifos, indicating potential therapeutic benefits.

Key Points

  • Lycopene significantly alleviated neurotoxicity caused by chlorpyrifos in rats, restoring neuronal function and homeostasis.
  • After 28 days, acetylcholinesterase levels recovered towards control values in lycopene-treated rats compared to chlorpyrifos alone.
  • Assessment using biochemical markers showed reduced oxidative stress and inflammation in the brain due to lycopene treatment.
  • Findings suggest lycopene may serve as a protective agent against organophosphate-induced neurotoxic effects.

Cite This Study

Bera et al. (2025) studied this question.

synapsesocial.com/papers/68c1c31b54b1d3bfb60f0ac7https://doi.org/10.32598/ijvm.19.4.1005731
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