Synthesis of Phenanthridines via Palladium-Catalyzed Annulation of 2-Iodobenzimines with 2-Halobenzoic Acids

Ying Fu; Hao Chen; Yu Luo; Wenying Yang; Luyao Jia; Zhengyin Du

doi:10.1039/d5qo00968e

January 1, 2025Organic Chemistry Frontiers

Synthesis of Phenanthridines via Palladium-Catalyzed Annulation of 2-Iodobenzimines with 2-Halobenzoic Acids

View Full Paper

Ask AI

Bookmark

Share

Key Points

The palladium-catalyzed reaction successfully synthesizes phenanthridines.
Calculations using density functional theory support the pathway of the annulation process.
The method employs 2-iodobenzimines and 2-halobenzoic acids as starting materials.
This work implies a significant advancement in the synthesis of complex organic molecules.

Implication

Development of a decarboxylative approach synthesizes phenanthridines from 2-halobenzoic acids, implying advances in organic synthesis.

Abstract

A palladium-catalyzed decarboxylative annulation reaction of 2-iodobenzimines with 2-halobenzoic acids for the synthesis of phenanthridine scaffolds has been developed. Density functional theory calculations revealed that in the presence of the...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Fu et al. (2025) studied this question.

synapsesocial.com/papers/68c1c32e54b1d3bfb60f14a8 https://doi.org/10.1039/d5qo00968e

View Full Paper

Ask AI

Bookmark

Share

Synthesis of Phenanthridines via Palladium-Catalyzed Annulation of 2-Iodobenzimines with 2-Halobenzoic Acids

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis of Phenanthridines via Palladium-Catalyzed Annulation of 2-Iodobenzimines with 2-Halobenzoic Acids

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading