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September 10, 2025The Indian Journal of Medical ResearchOpen Access

Relationship between vitamin D deficiency, vitamin D receptor gene variants, and the risk of coronary artery disease among South Indians: A case-control study

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Authors

NPNandini PrakashNMNagaraja MoorthyPSPandarisamy Sundaravadivel

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Overview

Case-control analysis reveals significant links between vitamin D deficiency, VDR variants, and CAD risk among South Indians, suggesting gender-specific implications.

Key Points

  • Vitamin D deficiency was observed in 90% of coronary artery disease patients compared to 63% of controls.
  • Those with vitamin D levels below 20 ng/ml had a 5.7-fold increased risk of coronary artery disease.
  • The VDR Taq I variant was associated with a reduced risk of coronary artery disease in overall analysis.
  • Fok I variant was linked to increased coronary artery disease risk in male participants, indicating gender disparities.

Cite This Study

Prakash et al. (2025) studied this question.

synapsesocial.com/papers/68c1c32e54b1d3bfb60f16a5https://doi.org/10.25259/ijmr_905_2024
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Links between vitamin D receptor gene polymorphisms and coronary artery disease: a review of evidence2025
  2. 2Vitamin D Receptor Gene Polymorphism in Type 1 Diabetes in South Indian Population.2026
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  4. 4Association of vitamin D status and vitamin D receptor polymorphism in diabetic foot ulcer patients: A prospective observational study in a South‐Indian tertiary healthcare facility2024 · 3 citations
  5. 5Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study2024 · 3 citations