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September 10, 2025CureusOpen Access

Delayed Diagnosis Salicylate Toxicity With Confirmed Cerebrospinal Fluid Salicylate Concentration: A Case Report of Altered Mental Status Without Neuroglycopenia and With Coagulopathy

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Case report highlights salicylate toxicity leading to altered mental status and coagulopathy, indicating the need for timely intervention.

Delayed recognition of salicylate toxicity resulted in dangerous complications, including coagulopathy.
The patient exhibited significantly elevated serum salicylate concentration of 48.8 mg/dL, indicating severe toxicity.
Analysis of cerebrospinal fluid (CSF) led to understanding salicylate-induced encephalopathy despite normal neuroglycopenia levels.
Rapid treatment of salicylate toxicity is critical to reduce morbidity and mortality associated with late diagnosis.

Singh et al. (2025) studied this question.

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Case report highlights salicylate toxicity leading to altered mental status and coagulopathy, indicating the need for timely intervention.