Observational findings reveal isolated palatal nodules as a sign of IgG4-related disease, highlighting diagnostic challenges.
Immunoglobulin G4-related disease (IgG4-RD) is a systemic, immune-mediated fibroinflammatory disorder characterized by tumor-like organ enlargement, dense lymphoplasmacytic infiltrates, and storiform fibrosis.¹ Early diagnosis is challenging when IgG4-RD presents as isolated palatal gland nodules, a rare and frequently overlooked manifestation of oral involvement.
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Wu et al. (2025) studied this question.
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