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September 10, 2025Journal of Neuroscience

Disrupted calcium dynamics in reactive astrocytes occur with endfeet-arteriole decoupling in an amyloid mouse model of Alzheimer’s disease

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Impaired calcium signaling fidelity was observed in reactive astrocytes of 5xFAD mice compared to wild types.
Evoked arteriole dilations in response to stimulation showed reduced coordination with astrocyte calcium transients in 5xFAD mice.
Synchronous activity within astrocyte networks was significantly compromised in the amyloid model of Alzheimer's disease.
Calcium response probability deficits suggest a breakdown in neurovascular communication essential for brain function.

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Implication

Investigation reveals impaired calcium signaling and arteriole coupling in reactive astrocytes in 5xFAD mice, suggesting significant pathophysiological implications.

Cite This Study

Weiss et al. (2025) studied this question.

synapsesocial.com/papers/68c1c9d254b1d3bfb60f2a47 https://doi.org/10.1523/jneurosci.0349-25.2025

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Implication

Investigation reveals impaired calcium signaling and arteriole coupling in reactive astrocytes in 5xFAD mice, suggesting significant pathophysiological implications.

Disrupted calcium dynamics in reactive astrocytes occur with endfeet-arteriole decoupling in an amyloid mouse model of Alzheimer’s disease

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Discussion

Implication

Cite This Study

Disrupted calcium dynamics in reactive astrocytes occur with endfeet-arteriole decoupling in an amyloid mouse model of Alzheimer’s disease

Key Points

Discussion

Implication

Cite This Study

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