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February 2, 2026Stroke

Abstract DP081: Impaired Electro-Calcium Coupling and Reduced Cerebral Blood Flow in the Early Stage of Alzheimer’s Disease

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Authors

HKHwoi Chan KwonNational Institutes of HealthAEAdrian M. EidenNational Institutes of HealthJLJoshua LiNational Institutes of Health

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Implication

Demonstrates reduced cerebral blood flow in a 5xFAD mouse model, indicating early vascular dysfunction leading to cognitive decline.

Key Points

  • Examine early cerebrovascular dysfunction in Alzheimer’s disease through the 5xFAD mouse model.
  • Used the 5xFAD mouse model at 3 months of age
  • Conducted in-vivo imaging with ASL MRI and fUS
  • Measured neuronal and endothelial calcium activity using fluorescence microscopy
  • Performed behavioral tests for cognitive assessment
  • No significant difference in resting cortical perfusion between 5xFAD and controls
  • Significant reduction in functional hyperemia in response to whisker stimulation in 5xFAD mice
  • Lower calcium activity in capillary endothelial cells in 5xFAD compared to controls
  • Inward rectifying K+ channel impairment observed in 5xFAD mice
  • Gradual cognitive decline noted in 5xFAD mice but not significantly different from controls

Cite This Study

Kwon et al. (2026) studied this question.

synapsesocial.com/papers/6980fbbec1c9540dea80d894https://doi.org/10.1161/str.57.suppl_1.dp081
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Alterations in Cardiovascular Parameters in 5xFAD Murine Model2025 · 2 citations
  2. 2Impaired cerebrovascular reactivity is associated with vascular smooth muscle cell loss in a mouse model of Alzheimer’s disease2025
  3. 3Restoring capillary-to-arteriole signaling in Alzheimer's Disease2024
  4. 4Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice2024 · 14 citations
  5. 5Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer’s disease2025 · 1 citations