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August 20, 2025Frontiers in Aging NeuroscienceOpen Access

Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer’s disease

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Authors

AEAlexander ErofeevEVE. K. VinokurovABAnastasia Bolshakova

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Overview

In vivo analysis reveals disrupted calcium dynamics and impaired electrophysiological activity during fear conditioning in 5xFAD mice, indicating cognitive decline in Alzheimer's disease.

Key Points

  • The research demonstrates significant deficits in learning and memory capacities of 5xFAD mice during fear conditioning.
  • Significant impairments in hippocampal-dependent contextual and tone-associated memory retrieval were observed in the study.
  • Using in vivo one-photon calcium imaging and electrophysiological recordings, the research explored neuronal alterations effectively.
  • Findings emphasize the importance of understanding neural dysfunctions in Alzheimer's disease for developing therapeutic strategies.

Cite This Study

Erofeev et al. (2025) studied this question.

synapsesocial.com/papers/68af4eb4ad7bf08b1ead75f2https://doi.org/10.3389/fnagi.2025.1550673
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Two-photon in vivo imaging of synaptic loss in 5XFAD mouse model of Alzheimer’s disease2026
  2. 2Abstract DP081: Impaired Electro-Calcium Coupling and Reduced Cerebral Blood Flow in the Early Stage of Alzheimer’s Disease2026
  3. 3Progressive Hippocampal Neuroarchitecture Changes in the 5×FAD Alzheimer’s Disease Mouse Model2025 · 5 citations
  4. 4Disruption of electrophysiological rhythms and memory impairment in an Alzheimer’s transgenic rat model2025
  5. 5Disruption of Ca <sub>V</sub> 2.3 channels in the brain of the 5xFAD mice2025