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October 12, 2025Journal of Integrative NeuroscienceOpen Access

Progressive Hippocampal Neuroarchitecture Changes in the 5×FAD Alzheimer’s Disease Mouse Model

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Authors

HJHyewon JangChonnam National UniversitySLSueun LeeKorea Institute of Oriental MedicineYKYeong-Jun KimChonnam National University

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Overview

Observational analysis shows behavioral impairments in 5×FAD mice, suggesting links to neuroinflammation and structural plasticity.

Key Points

  • Progressive impairments in fine motor coordination and working memory were observed in 5×FAD mice.
  • Significant age-related reductions in dendritic complexity were noted, including fiber crossing counts and total dendritic length.
  • Increased accumulation of amyloid β and phosphorylated tau correlated with synaptic protein decline as aging progressed.
  • The findings indicate disrupted synaptic transmission linked to neuroinflammation in the 5×FAD model.

Cite This Study

Jang et al. (2025) studied this question.

synapsesocial.com/papers/68ec1be02b8fa9b2b78ad393https://doi.org/10.31083/jin40831
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Also Consider

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  1. 1Progressive changes in synapses and glial cells in <i>AppNL-G-F</i> mice, a model of Alzheimer’s disease2025
  2. 2Behavioral characterization of olfactory, auditory, and motor deficits in 5×FAD mice2026
  3. 3Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice2024 · 14 citations
  4. 4Hippocampal grey matter changes across scales in Alzheimer's Disease2025
  5. 5Age dependent path integration deficit in 5xFAD mice2024 · 2 citations