What question did this study set out to answer?

This study aims to characterize age-related motor, olfactory, and auditory deficits in 5FAD mice while assessing associated pathological and neuroinflammatory changes.

May 24, 2026Journal of Veterinary ScienceOpen Access

Behavioral characterization of olfactory, auditory, and motor deficits in 5×FAD mice

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Authors

HJHyewon Jang SLSueun Lee YKYeongjun Kim

Discussion

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Overview

Randomized trial characterizes sensory and motor deficits in 5FAD mice, suggesting critical implications for Alzheimer's research.

Key Points

This study aims to characterize age-related motor, olfactory, and auditory deficits in 5FAD mice while assessing associated pathological and neuroinflammatory changes.
5FAD and control mice were tested at 3, 6, and 12 months.
Motor coordination was assessed using the rotarod test; olfactory and auditory performance were evaluated with the buried food test and acoustic startle response test.
Pathological analyses of amyloid- and glial activation were conducted using western blot and immunohistochemistry.
5FAD mice exhibited an age-dependent increase in passive clinging time on the rotarod.
There were progressive age-related impairments in olfactory performance and reduced acoustic startle responsiveness in the 5FAD group.
Pathological analyses revealed increases in amyloid- accumulation and glial activation in the olfactory bulb and auditory cortex with age.

Cite This Study

Jang et al. (2026) studied this question.

synapsesocial.com/papers/6a12955d48a0ea1665671853 https://doi.org/10.4142/jvs.26012

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May 24, 2026Journal of Veterinary ScienceOpen Access

Behavioral characterization of olfactory, auditory, and motor deficits in 5×FAD mice

View Full Paper

Ask AI

Bookmark

Authors

HJHyewon Jang SLSueun Lee YKYeongjun Kim

Discussion

Member takes

Overview

Randomized trial characterizes sensory and motor deficits in 5FAD mice, suggesting critical implications for Alzheimer's research.

Key Points

This study aims to characterize age-related motor, olfactory, and auditory deficits in 5FAD mice while assessing associated pathological and neuroinflammatory changes.
5FAD and control mice were tested at 3, 6, and 12 months.
Motor coordination was assessed using the rotarod test; olfactory and auditory performance were evaluated with the buried food test and acoustic startle response test.
Pathological analyses of amyloid- and glial activation were conducted using western blot and immunohistochemistry.
5FAD mice exhibited an age-dependent increase in passive clinging time on the rotarod.
There were progressive age-related impairments in olfactory performance and reduced acoustic startle responsiveness in the 5FAD group.
Pathological analyses revealed increases in amyloid- accumulation and glial activation in the olfactory bulb and auditory cortex with age.

Cite This Study

Jang et al. (2026) studied this question.

synapsesocial.com/papers/6a12955d48a0ea1665671853 https://doi.org/10.4142/jvs.26012

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