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February 13, 2026Behavioural Brain ResearchOpen Access

Fine Motor Function Deficits in the 5xFAD Mouse Model of Alzheimer’s Disease

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Authors

SVStylianos ValiantisNPNikolas PerentosAKAndreas M. Koupparis

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Overview

Experiments show impaired fine motor function in a mouse model of Alzheimer's disease, suggesting a link to age-related pathology.

Key Points

  • The research aimed to assess age-related changes in fine motor skills in the 5xFAD mouse model of Alzheimer's Disease.
  • Utilized behavioral tests, including rotarod, balance beam, and single-pellet reaching tests.
  • Examined mice at 3 and 9 months of age.
  • Compared performance of 5xFAD mice against wild-type (WT) controls.
  • 9M 5xFAD mice showed mild deficits in motor coordination on the rotarod test.
  • Demonstrated significantly slower traversal times and frequent slips on the balance beam test.
  • Impaired fine limb movements with reduced success rates and slower speed observed in the single-pellet reaching test.

Cite This Study

Valiantis et al. (2026) studied this question.

synapsesocial.com/papers/698ebeb185a1ff6a93015fc3https://doi.org/10.1016/j.bbr.2026.116097
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