What type of study is this?

September 10, 2025Applied Chemical EngineeringOpen Access

Development of bioactive heterocyclic compounds from trimethoprim: A new approach toward anticancer agents

View Full Paper

Ask AI

Bookmark

Authors

RARana Hussein Alwan MAMay Jaleel AbedUniversity of Al-Qadisiyah

Discussion

Member takes

Implication

Synthesis of heterocyclic derivatives from trimethoprim demonstrates significant cytotoxic activity against colon cancer cells, indicating new anticancer agents.

Key Points

The oxazine derivative (A9) displayed superior cytotoxic activity with an IC₅₀ of 0.1669 µg/mL against colon cancer cells.
The biological evaluation reveals notable cytotoxic activity in several trimethoprim-derived heterocyclic compounds.
Synthesis involved diazotization, aldol condensation, and cyclization reactions, confirming structural complexity.
Results suggest trimethoprim-derived heterocyclic scaffolds could be valuable in developing new anticancer agents.

Cite This Study

Alwan et al. (2025) studied this question.

synapsesocial.com/papers/68c1c9d254b1d3bfb60f2bed https://doi.org/10.59429/ace.v8i2.5704

View Full Paper

Ask AI

Bookmark

Implication

Synthesis of heterocyclic derivatives from trimethoprim demonstrates significant cytotoxic activity against colon cancer cells, indicating new anticancer agents.

Development of bioactive heterocyclic compounds from trimethoprim: A new approach toward anticancer agents

Discussion

Member takes

Implication

Key Points

Cite This Study

Development of bioactive heterocyclic compounds from trimethoprim: A new approach toward anticancer agents

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider