Case report highlights penile pain as a rare symptom of metastatic renal cell carcinoma, suggesting unique treatment needs.
Metastasis of a primary malignancy to the penis is rare with a limited number of reported cases this century. Of those cases, a small percentage are secondary to renal cell carcinoma, with most of these cases being caused by local invasion of prostate and bladder cancer. This report is that of a 70-year-old male who presented with penile swelling and pain, which was later determined to be secondary to metastatic renal cell carcinoma of the penis. Given the rarity of this disease process, the exact mechanism of invasion is still unknown and best treatment practices are based on symptomatic control.
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Murphy et al. (2025) studied this question.
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