Randomized clinical trial evaluated IC-CES effectiveness in major depressive disorder, suggesting mental health benefits.
This method presents a double-blind, randomized, parallel-group clinical trial aimed at personalizing cranial electrotherapy stimulation (CES) according to individual brain signals, assessing the effect of Intelligent Closed-Loop Cranial Electrotherapy Stimulation (IC-CES) on Major Depressive Disorder (MDD). Objective: To evaluate the effectiveness of IC-CES in treating MDD. Design: 120 participants were randomly assigned to either the IC-CES group or the CES group. Assessment: Depression, anxiety, and sleep quality were measured at multiple time points using standard questionnaires.
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Mosayebinejad et al. (2025) studied this question.
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