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September 10, 2025Scientific ReportsOpen Access

Adipocyte-derived factors induce adherent to suspension transition in breast and pancreatic cancer cells through lipid metabolic alteration

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Authors

DKDoru KwonJJJoon JeongBMByung Soh Min

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Overview

Experimental evaluation reveals adipocyte-mediated lipid metabolism enhances circulating tumor cell formation, indicating a role in metastasis.

Key Points

  • The study highlights how adipocyte-derived factors influence the transition of tumor cells from adherent to suspension.
  • Blocking fatty acid oxidation and CD36 significantly reduces the formation of circulating tumor cells, pointing to their pivotal role.
  • Research involved both in vitro dissemination assays and live-cell imaging, underscoring the importance of tumor-adipocyte interactions.
  • Preventing lipid metabolism impairs the formation of suspension cells and reduces their survival, emphasizing metabolic adaptability in tumors.

Cite This Study

Kwon et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc2354b1d3bfb60f3ee1https://doi.org/10.1038/s41598-025-13309-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 4120: Adherent-to suspension transition by hematopoietic factors in metastatic dissemination of circulating tumor cells2024
  2. 2Cancer-associated adipomes promote invadopodia formation and enhance metastatic potential in triple-negative breast cancer2026 · 2 citations
  3. 3Cancer-associated adipocytes: metabolic reprogramming, crosstalk and therapeutic implications in tumor progression2026
  4. 4Mechanisms of fatty acid metabolism in tumor metastasis and targeted therapeutic strategies.2026
  5. 5Adherent-to-suspension transition modulates circulating tumor cell dynamics and metastatic potential in melanoma2026 · 1 citations