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May 15, 2026Molecules and CellsOpen Access

Adherent-to-suspension transition modulates circulating tumor cell dynamics and metastatic potential in melanoma

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Authors

DLDong Ki LeeJOJongwook OhSLSoyeon Lee

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Overview

Randomized trial investigates the role of adherent-to-suspension transition in melanoma metastasis, suggesting it modulates tumor cell dynamics.

Key Points

  • This research aims to explore how adherent-to-suspension transition affects melanoma metastasis and circulating tumor cell dynamics.
  • Examined dynamics of adherent-to-suspension transition in metastatic melanoma.
  • Analyzed gene expression related to AST and EMT-like transition.
  • Performed clonal phylogenetic reconstruction to assess metastatic capacity of AST-high circulating tumor cells.
  • AST genes (IKZF1, IRF8, NFE2) enhance metastatic capacity in AST-high circulating tumor cells.
  • AST expression peaks in circulating tumor cells but reverts in established metastases.
  • AST-positive tumor cells localize near blood vessels, suggesting a role in facilitating blood-borne metastasis.

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/6a06b74ce7dec685947aa507https://doi.org/10.1016/j.mocell.2026.100368
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