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September 10, 2025Scientific ReportsOpen Access

Inflammatory cytokine interleukin-18 prevents murine miscarriage by inducing appropriate inflammation

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Authors

YHYumi HoriiNippon Medical SchoolHIHajime InoNippon Medical School HospitalFSF SasakiNippon Medical School

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Overview

This analysis demonstrates how interleukin-18 reduces miscarriage rates in pregnant mice, suggesting critical immune roles. Findings highlight inflammation's relationship with cytokines and miscarriage rates.

Key Points

  • Interleukin-18 significantly prevents miscarriage in murine models under low-dose LPS conditions, indicating its protective immune role.
  • Injection of anti-IL-18 antibody increased abortion rates among pregnant mice, showing the importance of interleukin-18 in preventing miscarriages.
  • The study utilized LPS-induced murine models to assess the impact of interleukin-18 and its associated cytokines on miscarriage rates.
  • Findings support the concept that interleukin-18 plays a critical role in regulating immune responses during pregnancy, with implications for miscarriage prevention.

Cite This Study

Horii et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc4754b1d3bfb60f4cb5https://doi.org/10.1038/s41598-025-16546-9
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