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September 1, 2005The Journal of Immunology

IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-τ

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Authors

GCG. ChaouatAMAines Assal MelianiJMJ. MartalDépartement Génétique Animale

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Overview

Experimental study demonstrates that interleukin-10 and interferon-tau reduce fetal resorption in abortion-prone mice, indicating anti-inflammatory cytokines protect the fetal allograft.

Key Points

  • To determine whether a local deficiency in anti-inflammatory Th2 cytokines drives pregnancy wastage in abortion-prone mice and whether restoring these cytokines improves fetal survival.
  • Assessed placental production of IL-4, IL-10, and inflammatory cytokines in abortion-prone CBA x DBA/2 matings compared to normal CBA x BALB/c matings.
  • Evaluated fetal resorption rates following in vivo intraperitoneal injections of recombinant IL-10, anti-IL-10 antibodies, anti-IFN-gamma, pentoxifylline, and recombinant ovine trophoblast protein (IFN-tau).
  • Intraperitoneal injection of recombinant IL-10 completely reversed the elevated incidence of fetal resorption in CBA x DBA/2 matings, whereas anti-IL-10 antibodies increased fetal wastage.
  • Dual administration of anti-IFN-gamma and the anti-TNF agent pentoxifylline induced synergistic remission of fetal resorption.
  • Administration of recombinant ovine IFN-tau counteracted fetal loss and simultaneously stimulated placental IL-4 and IL-10 production.

Cite This Study

Chaouat et al. (2005) studied this question.

synapsesocial.com/papers/6a99a66f951a91d49aabb0bbhttps://doi.org/10.4049/jimmunol.175.5.3447-d
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1TLR9 Inhibition Shortly After Mating Increases Fetal Resorption and Alters B- and T-Cell Costimulatory Phenotypes in an Abortion-Prone Mouse Model2026
  2. 2IL-10 Overexpression Reduces the Protective Response of an Experimental Chlamydia abortus Vaccine in a Murine Model2024
  3. 3Inflammatory cytokine interleukin-18 prevents murine miscarriage by inducing appropriate inflammation2025
  4. 4In-utero transfer of decidualized endometrial stromal cells increases the frequency of regulatory T cells and normalizes the abortion rate in the CBA/J × DBA/2 abortion model2024 · 5 citations
  5. 5IFN-τ Modulates PBMC Cytokine Profile and T Cell Phenotype to Improve Endometrial Immune Composition in the Implantation Window: A Combined In Vitro and In Vivo Study2025 · 1 citations