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September 10, 2025Scientific ReportsOpen Access

Enhancement of doxorubicin efficacy by diosmetin through DNA damage accumulation and P-glycoprotein inhibition in breast cancer cells

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Authors

MMMonika MichalczykMedical University of LublinEHEwelina HumeniukMedical University of LublinJKJoanna KubikMedical University of Lublin

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Implication

Investigating diosmetin's role in enhancing doxorubicin effects and reducing multidrug resistance in breast cancer.

Key Points

  • Diosmetin significantly enhances doxorubicin-induced apoptosis in breast cancer cells, pointing to its therapeutic potential.
  • Increased DNA damage was observed with doxorubicin when combined with diosmetin, reinforcing the drug's efficacy.
  • Diosmetin downregulates P-glycoprotein activity, a major contributor to multidrug resistance in cancer treatment.
  • Findings suggest diosmetin as a promising adjuvant therapy for overcoming resistance in breast cancer treatment.

Cite This Study

Michalczyk et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc4754b1d3bfb60f4ebdhttps://doi.org/10.1038/s41598-025-16681-3
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Also Consider

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  1. 1Mechanisms of doxorubicin-induced drug resistance and drug resistant tumour growth in a murine breast tumour model2019 · 210 citations
  2. 2Cardioprotective Effect of Centaurea castriferrei Borbás & Waisb Extract against Doxorubicin-Induced Cardiotoxicity in H9c2 Cells2023 · 4 citations
  3. 3Radiosensitizing effect of diosmetin on radioresistant lung cancer cells via Akt signaling pathway2017 · 51 citations
  4. 4P‐Glycoprotein‐Mediated Hoechst 33342 Transport Out of the Lipid Bilayer1997 · 144 citations