What does this research mean for the field?

Deinoxanthin (DNX) overcomes P-glycoprotein-mediated multidrug resistance in breast cancer cells by inhibiting P-gp drug efflux activity and suppressing its expression via modulation of the PI3K/AKT/NF-κB signaling pathway. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to evaluate the effectiveness of deinoxanthin in overcoming P-glycoprotein-mediated multidrug resistance in breast cancer cells.

June 10, 2026Journal of Biochemical and Molecular Toxicology

Deinoxanthin Overcomes P‐Glycoprotein‐Mediated Multidrug Resistance in Breast Cancer Cells

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This research aims to evaluate the effectiveness of deinoxanthin in overcoming P-glycoprotein-mediated multidrug resistance in breast cancer cells.
Isolated deinoxanthin and confirmed its structure using HPLC and spectroscopic analyses.
Conducted molecular docking studies to assess binding interactions with P-glycoprotein.
Performed functional assays to measure the intracellular accumulation of Calcein-AM and doxorubicin in the resistant MCF-7 cells.
DNX treatment significantly enhanced intracellular accumulation of Calcein-AM in MCF-7/DOX cells.
Combination of DNX with DOX restored drug sensitivity, demonstrated by a reduction in drug efflux and improved cytotoxicity.
DNX treatment suppressed P-glycoprotein overexpression and affected the PI3K/AKT/NF-κB signaling pathway.

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Implication

Randomized trial shows deinoxanthin enhances drug sensitivity in breast cancer cells, suggesting a novel approach for overcoming resistance.

Cite This Study

Babu et al. (2026) studied this question.

synapsesocial.com/papers/6a28fe716f82f25be989bb42 https://doi.org/10.1002/jbt.70961

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Implication

Randomized trial shows deinoxanthin enhances drug sensitivity in breast cancer cells, suggesting a novel approach for overcoming resistance.

Deinoxanthin Overcomes P‐Glycoprotein‐Mediated Multidrug Resistance in Breast Cancer Cells

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Discussion

Implication

Cite This Study

Deinoxanthin Overcomes P‐Glycoprotein‐Mediated Multidrug Resistance in Breast Cancer Cells

Key Points

Discussion

Implication

Cite This Study

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