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September 10, 2025ACS Applied Bio MaterialsOpen Access

Heavy-Atom-Free Aza-BODIPY Polymeric Nanoparticles for Theranostic-Guided Photodynamic Cancer Therapy

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Authors

PMPrapassara MuangsopaGYGong Yi YongYTYuranan Thathong

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Overview

In vitro findings show drug-delivering nanoparticles improve biocompatibility, indicating theranostic potential.

Key Points

  • The nanoparticles demonstrated significant photocytotoxicity upon irradiation in 4T1 cancer cells, indicating their effectiveness.
  • In vivo imaging confirmed that the nanoparticles targeted tumors with 2.5-fold greater efficacy than the parent compound.
  • OCT provided real-time monitoring of treatment effects in 3D cultures, suggesting enhanced tracking of therapeutic outcomes.
  • The developed nanoparticles showed excellent hemocompatibility and systemic biocompatibility, implying safety for clinical applications.

Cite This Study

Muangsopa et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc4754b1d3bfb60f4ecbhttps://doi.org/10.1021/acsabm.5c00878
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