This review demonstrates how mass spectrometry enhances understanding of mitochondrial health and diseases, suggesting profound implications for proteomics and lipidomics.
Mitochondria are key cellular organelles that perform essential functions, including energy generation, calcium regulation, and cell signaling. Disruptions in mitochondrial function are linked to various conditions, such as neurodegenerative disorders, metabolic diseases, and cardiovascular issues. This review critically analyzes the intricate relationship between mitochondrial health and disease, emphasizing the role of proteomics and lipidomics in enhancing the understanding of these processes. Powerful analytical strategies including various mass spectrometric techniques employed in these omic studies have been evaluated for their suitability and effectiveness. Additionally, it highlights the broader field of omics sciences and their integration into mitochondrial research. The aim is to illustrate how omics approaches play a crucial role in advancing biological knowledge related to mitochondria, surpassing the limitations of traditional analytical methods.
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Dhakne et al. (2025) studied this question.
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