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September 10, 2025Organic Letters

Rhodium(III)-Catalyzed C–H Activation/Annulation of Indoles with Cyclopropanols: A Rapid Assembly of Indole-Fused Diazepinones

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Authors

RLRan LiangJLJidan LiuFOFei-Hong Ouyang

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Overview

This catalytic approach demonstrates mild conditions and excellent atom-economy in creating indole derivatives, suggesting efficiency in synthesis.

Key Points

  • The method successfully synthesizes indole-fused diazepinones through Rh(III)-catalyzed reactions, showcasing effectiveness.
  • Notably, diverse products like eight-membered diazocino[7,8,1-hi]indol-5-ones and seven-membered azepino[3,4-b]indol-1(2H)-ones were obtained.
  • The approach merges sequential C-H and C-C bond cleavage, resulting in valuable products with excellent atom-economy.
  • This technique highlights the accessibility of starting materials and favorable reaction conditions for efficient synthesis.

Cite This Study

Liang et al. (2025) studied this question.

synapsesocial.com/papers/68c1d02354b1d3bfb60f63fchttps://doi.org/10.1021/acs.orglett.5c03198
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