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This catalytic approach demonstrates mild conditions and excellent atom-economy in creating indole derivatives, suggesting efficiency in synthesis.
The facile synthesis of indole-fused diazepinones via Rh(III)-catalyzed [4 + 3] annulation of indole derivatives with cyclopropyl alcohol by merging sequential C-H and C-C bond cleavage has been realized. Notably, the eight-membered diazocino[7,8,1-hi]indol-5-ones and seven-membered azepino[3,4-b]indol-1(2H)-ones could also be obtained via this tandem reaction strategy. This catalytic approach features mild reaction conditions, readily accessible starting materials, valuable products, and excellent atom-economy.
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Liang et al. (2025) studied this question.
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