This report outlines a new cycloaddition-lactonization method for constructing the ABDE ring system, suggesting innovative approaches for spiroaspertrione A precursors.
The synthesis of the ABDE ring system of spiroaspertrione A is reported. Construction of the DE ring system features a cycloaddition-lactonization strategy, followed by an efficient cyclopropanation and subsequent ring expansion to construct the cycloheptylfuranone core. A Michael addition was employed to join the AB and DE fragments, which ultimately revealed a strategy for the introduction of a second Michael acceptor, which we envision to be a key precursor to spiroaspertrione A.
No takes yet. Share an insight, caveat, or question.
Badart et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: