Randomized controlled trial assessed effects of creatine hydrochloride and creatine ethyl ester on cognition in perimenopausal and menopausal women, suggesting a potential targeted intervention.
Objective To investigate the effects of an 8-week supplementation with varying doses of creatine hydrochloride, administered alone or in combination with creatine ethyl ester, on cognitive function, clinical outcomes, brain creatine concentrations, and biochemical markers in perimenopausal and postmenopausal women. This study specifically aimed to evaluate the potential of low-dose creatine formulations with enhanced solubility as a targeted intervention for menopause-related neurocognitive and metabolic changes.
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Korovljev et al. (2025) studied this question.
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