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September 10, 2025ACS Applied Materials & Interfaces

Research on the Combined Antibacterial and Wound-Healing Effects of Oxygen-Carrying Hydrogel Photodynamic and Photothermal Therapy-Targeting Biofilms

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Authors

WZWeiwei ZhangYYYongqi YangXZXuanjun Zhang

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Overview

This innovative platform combines photodynamic and photothermal therapy to target biofilms, suggesting enhanced antibacterial efficacy.

Key Points

  • MCP@ZIF-8 achieved an antibacterial efficacy of up to 99%, effectively disrupting biofilms and providing significant wound healing benefits.
  • Nanoparticles embedded in hydrogel showed a photothermal therapy conversion efficiency of approximately 52.7% under near-infrared light.
  • Animal studies indicated that MCP@ZCP outperformed conventional treatments in promoting wound healing, enhancing overall therapeutic effectiveness.
  • Biosafety assessments confirmed that the platform is biocompatible and nontoxic, indicating potential for clinical applications in treating bacterial infections.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c1d22854b1d3bfb60f77a4https://doi.org/10.1021/acsami.5c11868
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