Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 16, 2026ACS Applied Materials & Interfaces

Multifunctional MoO3− X Nanozyme-Hydrogel for Synergistic Photothermal Antibacterial Therapy and Enhanced Healing of Wounds Infected with Drug‑Resistant Bacteria

View Full Paper
Ask AI
Bookmark
Share

Authors

WZWeiwei ZhangSouth China Agricultural UniversityLFLixiang FanAnhui Polytechnic UniversityXZXuanjun ZhangLinköping University

Discussion

Loading...

Member takes

Overview

Preclinical study demonstrates synergistic photothermal and catalytic bacterial clearance in infected murine wounds, indicating potential for treating multidrug-resistant infections.

Key Points

  • To develop an oxygen-vacancy-rich MoO3-X nanozyme-loaded hydrogel capable of synergistic photothermal and catalytic therapy for multidrug-resistant bacterial infections and accelerated wound healing.
  • Synthesized MoO3-X nanozymes embedded in a dynamic network of L-glutamine-grafted chitosan and oxidized dextran.
  • Characterized photothermal conversion under 808 nm near-infrared irradiation and assessed in vitro antimicrobial efficacy against multidrug-resistant Escherichia coli and Staphylococcus aureus biofilms.
  • Evaluated in vivo wound closure, biosafety, and expression of vascular endothelial growth factor (VEGF) and tumor necrosis factor-α (TNF-α) in an infected murine model.
  • The hydrogel achieved a 49.70% photothermal conversion efficiency and exhibited robust peroxidase-like activity.
  • Near-infrared irradiation (808 nm) enabled >99% eradication of both MDR E. coli and S. aureus as well as significant biofilm disruption.
  • In vivo application significantly accelerated wound closure, up-regulated VEGF, down-regulated TNF-α, and showed strong biocompatibility.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a8179dcf2fb91fc834ad3e1https://doi.org/10.1021/acsami.6c11162
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Self-Oxygenating Nano-Thermosensitive Hydrogel System Integrated with Photothermal/Photodynamic Therapy for Antibacterial Therapy and Enhanced Wound Healing2025 · 3 citations
  2. 2A Multifunctional MXene@CeO <sub>2</sub> ‐Enhanced Hydrogel Dressing for Synergistic Photothermal Antibacterial and Antioxidative Therapy in Wound Healing2025 · 9 citations
  3. 3NIR‐Triggered On‐Demand Synergistic Therapy for Multidrug‐Resistant Bacterial Infections Via a Smart Phase‐Transition Hydrogel2026
  4. 4Bio-heterojunction-engineered recombinant collagen hydrogel orchestrates multimodal sterilization and immunomodulation for MRSA-infected wound healing2026 · 2 citations
  5. 5Research on the Combined Antibacterial and Wound-Healing Effects of Oxygen-Carrying Hydrogel Photodynamic and Photothermal Therapy-Targeting Biofilms2025