What question did this study set out to answer?

To engineer a multifunctional nanocomposite hydrogel dressing combining cerium dioxide-doped MXene nanosheets with modified gelatin for synergistic photothermal bacterial elimination and tissue regeneration in infected wounds.

June 26, 2025Advanced Healthcare Materials

A Multifunctional MXene@CeO ₂ ‐Enhanced Hydrogel Dressing for Synergistic Photothermal Antibacterial and Antioxidative Therapy in Wound Healing

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To engineer a multifunctional nanocomposite hydrogel dressing combining cerium dioxide-doped MXene nanosheets with modified gelatin for synergistic photothermal bacterial elimination and tissue regeneration in infected wounds.
Synthesized cerium dioxide-doped MXene nanosheets (MXene@CeO2) and incorporated them into a UV-crosslinked glycidyl methacrylate-modified gelatin matrix.
Evaluated electrostatic bacterial capture in acidic environments along with near-infrared (NIR) photothermal eradication of drug-resistant bacteria and biofilms.
Assessed antioxidative capabilities, macrophage polarization, in vitro cell migration and angiogenesis, and in vivo wound closure efficacy.
Facilitated acidic microenvironment-driven electrostatic capture of bacteria and achieved robust photothermal destruction of drug-resistant strains and bacterial biofilms under NIR irradiation.
Alleviated oxidative stress, promoted cellular migration and vascularization, and stimulated macrophage phenotype switching toward an anti-inflammatory state.
Accelerated wound closure and enhanced tissue regeneration in vivo compared to untreated controls.

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Implication

Preclinical study reveals that an NIR-responsive nanocomposite hydrogel accelerates wound closure in bacterial infections, highlighting a potent strategy against antibiotic resistance.

Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/6a1a25af1be374a25e5b52d2 https://doi.org/10.1002/adhm.202500656

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Implication

Preclinical study reveals that an NIR-responsive nanocomposite hydrogel accelerates wound closure in bacterial infections, highlighting a potent strategy against antibiotic resistance.

A Multifunctional MXene@CeO ₂ ‐Enhanced Hydrogel Dressing for Synergistic Photothermal Antibacterial and Antioxidative Therapy in Wound Healing

Key Points

Discussion

Implication

Cite This Study

A Multifunctional MXene@CeO ₂ ‐Enhanced Hydrogel Dressing for Synergistic Photothermal Antibacterial and Antioxidative Therapy in Wound Healing

Key Points

Discussion

Implication

Cite This Study

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