Research reveals new tetrahydroaphcosterones from Juglans mandshurica, with notable cytotoxicity against cancer cell lines.
Two new compounds (1-2) and thirteen known tetrahydroaphcosterones (3-15) were isolated from the green walnut husks of Juglans mandshurica, with structures elucidated via spectroscopic analyses. Cytotoxicity screening against BGC-823, A-549, and HepG-2 cancer cell lines revealed that compound 12 inhibited A-549 with the IC50 value of (54.94 ± 1.72) μM. Compounds 3-4 and 10-12 inhibited HepG-2, and the IC50 values were (62.53 ± 2.52), (51.95 ± 0.65), (63.90 ± 0.30), (66.60 ± 1.35), (61.07 ± 0.31) μM. Compounds 4 and 12 inhibited BGC-823 at 60 μM. This study identifies bioactive components and provides a chemical foundation for clinical preparation development.
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