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September 10, 2025International Journal of Antimicrobial AgentsOpen Access

The Impact of Probiotics on Helicobacter pylori Eradication with Bismuth Quadruple Therapy: A Systematic Review and Meta-Analysis

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Authors

YLYi LiuShandong University of Traditional Chinese MedicineJZJu ZhangNortheast Agricultural UniversityDLDandan LiTsinghua University

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Overview

Systematic review finds probiotics improve eradication rates and reduce adverse events in patients.

Key Points

  • Probiotic-supplemented bismuth quadruple therapy significantly improved eradication rates for H. pylori.
  • Nineteen RCTs with 2973 samples showed PBQT resulted in lower adverse events, especially diarrhea and nausea.
  • Subgroup analysis revealed that Saccharomyces boulardii notably enhanced eradication rates in treated patients.
  • Findings suggest the integration of PBQT could optimize H. pylori treatment protocols in clinical settings.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c1d22854b1d3bfb60f7812https://doi.org/10.1016/j.ijantimicag.2025.107600
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