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September 10, 2025Journal of Inflammation ResearchOpen Access

MiR-491-5p Targets B4GalT5 to Alleviate Airway Inflammation and Remodeling in Asthma by Regulating Pulmonary Oxidative Stress

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Authors

FGFan GaoHZHe ZhuJLJiahui Lei

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Overview

Research demonstrates miR-491-5p reduces airway inflammation and remodeling in asthma, highlighting B4GalT5 and oxidative stress as key pathways.

Key Points

  • MiR-491-5p overexpression significantly alleviated airway inflammation and remodeling in an asthma model.
  • Clinical analysis revealed B4GalT5 expression correlated positively with markers of airway remodeling like Ki-67.
  • Oxidative stress factors, including ROS and MDA levels, were notably reduced following miR-491-5p treatment.
  • Mechanistic studies confirmed miR-491-5p targets B4GalT5, inhibiting its expression and regulating oxidative stress pathways.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/68c1d22854b1d3bfb60f78b3https://doi.org/10.2147/jir.s544437
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1miR‐16‐5p Attenuated Airway Inflammation and Pulmonary Fibrosis of Asthma Rats by Regulating the TGF‐β1/Smad3 Signaling2026
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  5. 5The miR-3164/PAD4 axis regulates NETosis to prevent airway inflammation and remodeling through the TLR2/NF-κB signaling pathway2025