Key result
Modulating miR-185-5p regulates airway periostin expression and smooth muscle contraction via CDC42 and RhoA.
Why the study?
The role of miR-185-5p in regulating periostin secretion and smooth muscle contraction related to airway remodeling in asthma was not well understood.
Population
Bronchial smooth muscle cells and small airway epithelial cells from healthy subjects; sputum from healthy and asthmatic subjects
Comparison
miR-185-5p mimic and inhibitors vs control
Design
Preclinical experimental study
Authors
Loading...
No immediate change to asthma care; leaves open miR-185-5p–periostin targeting for further mechanistic and clinical validation.
miR-185-5p modulates periostin secretion and smooth muscle contraction in airway structural cells, highlighting its potential as a therapeutic target in asthma.
Rodrigo‐Muñoz et al. (2021) studied Asthma. miR-185-5p modulation was evaluated on Periostin secretion and smooth muscle contraction. Modulation of miR-185-5p regulated periostin expression in airway structural cells and smooth muscle contraction via CDC42 and RhoA, with diminished miR-185-5p seen in asthmatic sputum.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: