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August 26, 2025Molecular CancerOpen Access

Retraction Note: m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling

Min Kang Yunshan Wang Yan Wang Yin Bi Songqing He Fumio Shimamoto Bo Tang Yihua Yang

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Key Points

ALKBH5 decreases WIF-1 RNA methylation, inhibiting pancreatic cancer tumorigenesis.
The study shows that manipulation of m6A levels affects Wnt signaling pathways.
Investigation involved analyses of ALKBH5's role in cancer cell growth and metabolic regulation.
Retraction highlights the need for validation in studies involving RNA modifications in cancer.

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Implication

Retraction note reveals that ALKBH5 inhibits tumorigenesis in pancreatic cancer by impacting RNA methylation and Wnt signaling.

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Cite This Study

Kang et al. (2025) studied this question.

synapsesocial.com/papers/68c1d22854b1d3bfb60f7968 https://doi.org/10.1186/s12943-025-02432-5

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