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September 10, 2025The World Journal of Men s HealthOpen Access

Induction of Spermatogenesis and Its Predictors in Men with Prepubertal-Onset Hypogonadotropic Hypogonadism Undergoing Gonadotropin Therapy

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Authors

MCMin Chul ChoSeoul National University HLHohyun LeeSeoul National University Hospital SKSoo Woong KimSeoul National University Hospital

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Implication

Retrospective analysis demonstrates successful spermatogenesis in 82% of men with hypogonadotropic hypogonadism, suggesting testicular volume is a key predictor.

Key Points

Spermatogenesis was successfully induced in 82% of men receiving gonadotropin therapy, with median induction time being 7.5 months.
Significant treatment outcomes include a median testosterone increase from 0.10 ng/mL to 3.16 ng/mL after initial therapy.
Larger baseline testicular volume was identified as the sole predictor of successful spermatogenesis outcomes.
Among the men seeking conception, 67% achieved pregnancy following gonadotropin therapy.

Cite This Study

Cho et al. (2025) studied this question.

synapsesocial.com/papers/68c1d23054b1d3bfb60f7b81 https://doi.org/10.5534/wjmh.250117

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Implication

Retrospective analysis demonstrates successful spermatogenesis in 82% of men with hypogonadotropic hypogonadism, suggesting testicular volume is a key predictor.

Induction of Spermatogenesis and Its Predictors in Men with Prepubertal-Onset Hypogonadotropic Hypogonadism Undergoing Gonadotropin Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Induction of Spermatogenesis and Its Predictors in Men with Prepubertal-Onset Hypogonadotropic Hypogonadism Undergoing Gonadotropin Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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