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September 10, 2025Annals of Intensive CareOpen Access

Serum proteomes and their prognostic values in sepsis patients admitted to a medical intensive care unit: a single-center study using SWATH-MS proteomics

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Single-center study demonstrates a six-variable model predicts mortality in sepsis patients, highlighting serum proteomics biomarkers.

Increased levels of ACTB were linked to higher in-hospital mortality, revealing its prognostic potential.
The six-variable model, integrating SOFA scores and key proteins, achieved an AUC of 0.903 for mortality prediction.
Retrospective cohort analysis of 217 sepsis patients used advanced proteomics to identify critical biomarkers.
These findings may enable improved risk stratification for sepsis patients in intensive care settings.

Lee et al. (2025) studied this question.

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