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September 10, 2025Cancer ImagingOpen Access

Machine Learning–Driven radiomics on 18 F-FDG PET for glioma diagnosis: a systematic review and meta-analysis

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Authors

ASAli ShahriariZabol UniversitySASasan Ghazanfar AhariTabriz University of Medical SciencesAMAli MousaviTabriz University of Medical Sciences

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Implication

Systematic review and meta-analysis demonstrate robust diagnostic accuracy of ML models for glioma, suggesting methodological improvements are essential.

Key Points

  • ML models based on 18F-FDG PET radiomics achieve a pooled accuracy of 92.6%, showcasing their diagnostic potential for glioma classification.
  • The meta-analysis included data from 12 studies with 2,321 patients, revealing significant heterogeneity and the influence of ML model type on results.
  • Random-effects models analyzed diagnostic metrics, including AUC of 0.95 and sensitivity of 85.4%, indicating strong performance across various ML approaches.
  • High methodological heterogeneity calls for standardized reporting and validation methods before clinical application of these models.

Cite This Study

Shahriari et al. (2025) studied this question.

synapsesocial.com/papers/68c1d24654b1d3bfb60f8607https://doi.org/10.1186/s40644-025-00915-8
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