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September 10, 2025Open Access

Prognostic Significance of Tumor Budding in Early Oral Tongue Squamous Cell Carcinoma with Shallow Depth of Invasion

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Authors

HYHiroya YonagaShizuoka Cancer CenterTMTakashi MukaigawaShizuoka Cancer CenterSMShinya MoritaShizuoka Cancer Center

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Implication

Retrospective analysis reveals tumor budding as a key risk indicator for cervical lymph node metastasis in OTSCC.

Key Points

  • Tumor budding is identified as a significant prognostic factor for late cervical lymph node metastasis.
  • Among 107 patients, neck recurrence occurred in 9 individuals within 3 years, highlighting poor outcomes.
  • Multivariate analysis confirmed that tumor budding ≥ 5 serves as an independent risk indicator for metastasis.
  • Incorporating tumor budding with depth of invasion enhances predictive performance for identifying high-risk cases.

Cite This Study

Yonaga et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5e554b1d3bfb60f8816https://doi.org/10.21203/rs.3.rs-7266517/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of Depth of Invasion in Node‐Negative Oral Tongue Cancer Treated With Surgery Alone2025 · 5 citations
  2. 2Prognostic role of tumor budding in oral squamous cell carcinoma: a retrospective study2024 · 1 citations
  3. 3Refining Risk Stratification in Oral Squamous Cell Carcinoma: The Role of Tumor Budding and Worst Pattern of Invasion2026
  4. 4Evaluation of prognostic factors for oral tongue squamous cell carcinoma: Significance of intratumoral tumor-infiltrating lymphocytes, lymph node ratio, and depth of invasion.2024
  5. 5The role of Depth of Invasion as a prognostic factor in Oral Squamous Cell Carcinoma2025