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September 10, 2025Journal of ToxicologyOpen Access

Preclinical Safety Assessment of an Ayurvedic Dentifrice: Acute and 28‐Day Oral Toxicity Studies in Wistar Albino Rats

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Authors

DFDelfin Lovelina FrancisSRSaravanan Sampoornam Pape ReddyBMBalaji Manohar

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Overview

Preclinical study reveals the ayurvedic dentifrice formulation shows no significant oral toxicity in Wistar albino rats, suggesting potential safety for use.

Key Points

  • The ayurvedic dentifrice formulation showed no significant mortality or clinical signs in the tested rats.
  • At doses up to 2000 mg/kg body weight, hepatic changes were minor and reversible, indicating safety.
  • The no-observed-adverse-effect level at 1000 mg/kg supports further investigation for human application.
  • Long-term clinical trials are recommended to confirm safety for oral use in humans.

Cite This Study

Francis et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5e554b1d3bfb60f8a37https://doi.org/10.1155/jt/1379571
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