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September 10, 2025Acta DiabetologicaOpen Access

Serum uric acid to HDL-Chol ratio (UHR) is associated with insulin resistance/sensitivity in individuals without diabetes

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Authors

MRMariangela RubinoMagna Graecia UniversityMMMattia MassiminoMagna Graecia UniversityEMElettra MancusoMagna Graecia University

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Overview

This research investigates the link between uric acid to HDL cholesterol ratio and insulin resistance, suggesting UHR may serve as a metabolic risk marker.

Key Points

  • Uric acid to HDL cholesterol ratio (UHR) shows strong correlations with insulin resistance indicators.
  • In two independent cohorts, UHR positively correlates with HbA1c, fasting insulin, and triglycerides.
  • The study highlights statistical significance in the association of UHR with metabolic risk factors.
  • UHR's easy derivation from routine measurements suggests its potential in early diabetes prevention strategies.

Cite This Study

Rubino et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5ef54b1d3bfb60f8bd8https://doi.org/10.1007/s00592-025-02576-2
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